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Elevated osteopontin levels in active relapsing-remitting multiple sclerosis

✍ Scribed by Mario H. J. Vogt; Luba Lopatinskaya; Monique Smits; Chris H. Polman; Lex Nagelkerken

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
67 KB
Volume
53
Category
Article
ISSN
0364-5134

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✦ Synopsis

Abstract

In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine‐encoding gene expressed within MS lesions. Here, we report significantly increased OPN protein levels in plasma of relapsing‐remitting MS patients. In contrast, OPN protein levels in primary progressive and secondary progressive MS patients were similar to healthy control levels. Interestingly, active relapsing‐remitting patients had higher OPN protein levels than patients without relapses. Ann Neurol 2003;53:819–822

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