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Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

✍ Scribed by Wolfman, Alan; Macara, Ian G.


Book ID
109748181
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
396 KB
Volume
325
Category
Article
ISSN
0028-0836

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Translocation of diacylglycerol kinase f
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The tumor-promoting phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate, causes a rapid, partial redistribution of 1,2-diacylglycerol kinase from the cytosol to the particulate fraction of quiescent Swiss 3T3 fibroblasts. The inactive alpha form of the phorbol ester does not cause any change in dia