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Elevated expression of erbB3 confers paclitaxel resistance in erbB2-overexpressing breast cancer cells via upregulation of Survivin

โœ Scribed by Huang, X; Lee, C-K; Liu, B; Wang, S

Book ID
109972377
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
927 KB
Volume
29
Category
Article
ISSN
0950-9232

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## Abstract Receptor tyrosine kinase activity is essential for erbB2 (HER2/__neu__) promotion of breast carcinogenesis, metastasis and therapeutic resistance. erbB2 kinase can be activated by dimerization with another erbB receptor, most of which bind ligands. Of these, the erbB2/erbB3 heterodimer