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Elevated Expression of DNA Polymerase β Gene in Glioma Cell Lines with Acquired Resistance to 1-(4-Amino-2-methyl- 5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea

✍ Scribed by Akira Gomi; Souji Shinoda; Ryuichi Sakai; Hisamaru Hirai; Keiya Ozawa; Toshio Masuzawa


Book ID
115579212
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
217 KB
Volume
227
Category
Article
ISSN
0006-291X

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## Abstract 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline (IQ) and 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__)]pyridine (PhIP) are two members of a family of carcinogenic heterocyclic amines (HAs) found in cooked meats that form DNA adducts after activation to __N__‐acetoxy derivatives. The ability of IQ