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Elevated expression of CCL5/RANTES in adult T-cell leukemia cells: Possible transactivation of the CCL5 gene by human T-cell leukemia virus type I tax

✍ Scribed by Naoki Mori; Alan M. Krensky; Koichi Ohshima; Mariko Tomita; Takehiro Matsuda; Takao Ohta; Yasuaki Yamada; Masao Tomonaga; Shuichi Ikeda; Naoki Yamamoto

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
991 KB
Volume
111
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

HTLV‐I is the etiologic agent of ATL and of tropical spastic paraparesis/HTLV‐I‐associated myelopathy. Infiltration of various tissues by circulating leukemic cells and HTLV‐I‐infected T cells is a characteristic of ATL and HTLV‐I‐associated inflammatory diseases. Chemokines play important roles in migration and tissue localization of various lymphocyte subsets. Here, we report the highly frequent expression of CCL5 (RANTES) in ATL and HTLV‐I‐infected T‐cell lines. Among various human T‐cell lines, those infected with HTLV‐I selectively expressed the CCL5 gene and secreted CCL5. Furthermore, CCL5 was expressed by leukemic cells in peripheral blood and lymph nodes from patients with ATL. Inducible expression of HTLV‐I transcriptional activator Tax in a human T‐cell line Jurkat, up‐regulated CCL5 mRNA and induced CCL5 secretion. Analysis of the CCL5 promoter revealed that this gene is activated by Tax, via the activation of NF‐κB, whose responsive element, R(A/B), is located at positions −71 to −43 relative to the putative transcription start site. Aberrant expression of CCL5 by HTLV‐I‐infected T cells may impact on the pathophysiology of HTLV‐I‐associated diseases. © 2004 Wiley‐Liss, Inc.

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