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ELEVATED EXPRESSION OF AKR1C2 AND AKR1C3 IN PROSTATE CANCER CELLS PROMOTES ANGIOGENESIS IN VITRO

✍ Scribed by Azzarello, Joseph; Wang, Shaobin; Fung, Kar-Ming; Kropp, Bradley P; Lin, Hsueh-Kung

Book ID: 122729272
Publisher: Lippincott Williams and Wilkins
Year: 2008
Tongue: English
Weight: 147 KB
Volume: 179
Category: Article
ISSN: 0022-5347
DOI: 10.1016/S0022-5347(08)61342-7

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## Abstract Dihydrodiol dehydrogenase (DDH) is a member of the aldo‐keto reductases superfamily (AKR1C1–AKR1C4), which plays central roles in the metabolism of steroid hormone, prostaglandin and xenobiotics. We have previously detected overexpression of DDH as an indicator of poor prognosis and che