✦ LIBER ✦

Elevated concentration of cerebrospinal fluid tissue transglutaminase in Parkinson's disease indicating apoptosis

✍ Scribed by Istvan Vermes; Ernst N.H. Jansen Steur; Gustav F. Jirikowski; Clemens Haanen

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 57 KB
Volume: 19
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20197

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Tissue transglutaminase (tTG) is activated during the apoptotic cell death cascade and plays a key role in the formation of apoptotic bodies. We found significant elevation of tTG concentration in the cerebrospinal fluid (CSF) of 54 patients with Parkinson's disease (PD) compared with that measured in 34 control subjects, thus showing increased neural cell apoptosis in patients with PD. © 2004 Movement Disorder Society

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