𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Elevated carcinoembryonic antigen levels correlating with disease recurrence in a patient with adenoid cystic carcinoma

✍ Scribed by Dr. William I. Kuhel; Dr. Harold Chow; Dr. Thomas A. Godwin; Dr. C. Richard Minick; Dr. Daniel M. Libby

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
580 KB
Volume
17
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Background. Carcinoembryonic antigen (CEA) is an oncofetal glycoprotein involved in cell recognition and adhesion. Serum CEA has been extensively studied as a potential chemical marker for malignancy, most notably in patients with colon carcinoma. Serum CEA measurements have not been reported for patients with salivary gland carcinomas.

Methods. Serum CEA was measured in a case study using enzyme immunoassay with monoclonal antibody specific for CEA. Tissue was examined with standard histologic and immunohistologic methods.

Results. A patient was initially seen with adenoid cystic carcinoma (ACC) of the trachea and had a markedly elevated serum CEA level which declined after surgical resection. The serum CEA level became elevated again when the patient developed abdominal metastases and then declined after debulking of the tumor. lmmunohistochemical study of the tumor was positive for CEA.

Conclusions. The measurement of serum CEA levels may play a role in the management of patients with ACC. Clinical investigation utilizing monoclonal antibodies against CEA, for imaging and for the delivery of chemotherapy and radiotherapy may be worthwhile.

πŸ“œ SIMILAR VOLUMES

Tumor-associated glycoprotein-72 serum l
Tumor-associated glycoprotein-72 serum levels complement carcinoembryonic antigen levels in monitoring patients with gastrointestinal carcinoma. A lingitudinal study
✍ Fiorella Guadagni; Mario Roselli; Teresa Amato; Maurizio Cosimelli; Ernesto Mann πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 696 KB

Eighty-two patients diagnosed with gastrointestinal (GI) adenocarcinoma were evaluated before and for 26 months after primary tumor resection for the presence of two serum tumor markers: tumor-associated glycoprotein-72 (TAG-72) and carcinoembryonic antigen (CEA). Elevated TAG-72 and CEA serum level

Circulating D-dimer levels are better pr
Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma
✍ Kimberly Blackwell; Herbert HurαΊƒitz; Grazyna LiebΓ©rman; William Novotny; Stacey πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 114 KB

## Abstract ## BACKGROUND Fibrin formation is required for tumor angiogenesis, metastasis, and invasion. D‐dimer, a fibrin degradation product, is produced when crosslinked fibrin is degraded by plasmin. The current study prospectively examined D‐dimer levels in patients with metastatic colorectal