Elevated brain iron is independent from atrophy in Huntington's Disease
โ Scribed by Eve M. Dumas; Maarten J. Versluis; Simon J.A. van den Bogaard; Matthias J.P. van Osch; Ellen P. Hart; Willeke M.C. van Roon-Mom; Mark A. van Buchem; Andrew G. Webb; Jeroen van der Grond; Raymund A.C. Roos
- Book ID
- 119332520
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 744 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1053-8119
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The topographic distribution of brain atrophy was quantified by image analysis of fixed coronal brain slices from 12 patients dying with Huntington's disease (HD) and from 4 other patients dying with progressive supranuclear palsy (PSP). In HD, atrophy was maximal within the caudate nucleus, putamen
Huntington's disease (HD) produces progressive and ultimately widespread impairment of brain function. Neostriatal atrophy alone cannot account for whole-brain losses seen postmortem, and the mutant huntingtin protein and its neuropathologic sequelae are evident throughout the brain. Whole-brain atr