The ability of two enantiomeric fluoro-analogues of D-myo-inositol 1,4,5trisphosphate [Ins(1,4,5)P3] to mobilize intracellular Ca2+ stores in SH-SY5Y neuroblastoma cells has been investigated. ( -)-~-2,2-difluoro-2-deoxy-myo-Ins(1,4,5)P~ [~-2,2-F2 -Ins(1,4,5)P3] was a full agonist [ECm 0.21 pA4l and
โฆ LIBER โฆ
Elevated [3H]inositol 1,4,5-trisphosphate binding sites and expressed inositol 1,4,5-trisphosphate receptor protein level in platelets of depressed patients
โ Scribed by Yogesh Dwivedi; Philip G. Janicak; G. N. Pandey
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 214 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0033-3158
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We studied the alterations of calcium accumulation and intracellular signal transduction using autoradiography of the second messenger system in order to clarify the mechanisms of the delayed neuronal changes in the remote areas of rat brain after transient focal ischemia. Chronological changes of 4