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Elements of the nitric oxide/cGMP pathway expressed in cerebellar granule cells: biochemical and functional characterisation

✍ Scribed by Sandra Jurado; José Sánchez-Prieto; Magdalena Torres


Book ID
116764530
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
376 KB
Volume
45
Category
Article
ISSN
0197-0186

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Ca2+ entry induced by N-methyl-D-aspartate (NMDA) in neurons and by noradrenaline (NA) in astrocytes is known to increase intracellular cyclic GMP (cGMP) levels through stimulation of the Ca2+-dependent nitric oxide synthase type I (NOS-I). The possibility that Ca2+ entry could also down-regulate in