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Electrostatic surface modifications to improve gene delivery

✍ Scribed by Shmueli, Ron B; Anderson, Daniel G; Green, Jordan J


Book ID
121254524
Publisher
Informa plc
Year
2010
Tongue
English
Weight
688 KB
Volume
7
Category
Article
ISSN
1742-5247

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Biodegradable polymeric nanoparticles are currently being explored as a nonviral gene delivery system; however, many obstacles impede the translation of these nanomaterials. For example, nanoparticles delivered systemically are inherently prone to adsorbing serum proteins and agglomerating as a resu