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Electrostatic modifications of the human leukocyte antigen DR P9 peptide-binding pocket in primary sclerosing cholangitis: Back to the future with human leukocyte antigen DRβ

✍ Scribed by Peter T. Donaldson


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
66 KB
Volume
53
Category
Article
ISSN
0270-9139

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Electrostatic modifications of the human
✍ Johannes R. Hov; Vasilis Kosmoliaptsis; James A. Traherne; Marita Olsson; Kirste 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 669 KB

The strongest genetic risk factors for primary sclerosing cholangitis (PSC) are found in the human leukocyte antigen (HLA) complex at chromosome 6p21. Genes in the HLA class II region encode molecules that present antigen to T lymphocytes. Polymorphisms in these genes are associated with most autoim