๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Electrostatic interactions and ion transport in narrow channels: the model system gramicidin

โœ Scribed by Miguel Sancho

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
725 KB
Volume
97
Category
Article
ISSN
0167-2738

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โœฆ Synopsis

This paper reviews the main theoretical approaches proposed to understand ion permeation in gramicidin, a model for more complex biological ion channels. Continuum and molecular dynamics viewpoints have contributed to significant insights in the essential transport mechanisms. The focus is on the recent semi-microscopic approach which analyzes the microscopic single file aspects of the system without neglecting the long range macroscopic effect of both solvent and membrane.

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## Abstract The coupling of the constitutive expression for the electrostatic potential as specified through Poisson's equation together with the constitutive equations for the mechanisms of convection, diffusion, electrophoretic migration, and adsorption provides the necessary set of constitutive