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Electrostatic effects in acylation of hemoglobin by aspirins

✍ Scribed by Solomon E. Massil; Guey-Yueh Shi; Irving M. Klotz

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
368 KB
Volume
73
Category
Article
ISSN
0022-3549

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✦ Synopsis

I. we observed two different kinds of phonon and intramolecular spectra, one belonging to the sulfathiazole A form and the other being the polymorphic form obtained from propanol. The method of preparation (i.e., temperature and/or concentration of solution) probably determines which of the two forms of sulfathiazole is present in the conjugates with drug-polymer ratios of 3: I -1:l.S. No other crystalline forms of sulfathiazole were observed in the drug-polymer conjugates. We therefore attribute the higher dissolution rate observed to arise from the particle size reduction of the drug in the presence of the polymer, whereby the increased effective surface area leads to an enhanced dissolution rate.

REFERENCES

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