Electrospray–differential mobility analysis as an orthogonal tool to size-exclusion chromatography for characterization of protein aggregates

Size exclusion chromatography coupled to

Size exclusion chromatography coupled to electrospray ionization mass spectrometry for analysis and quantitative characterization of arsenic interactions with peptides and proteins

✍ Anne-Christine Schmidt; Benjamin Fahlbusch; Matthias Otto 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 612 KB

## Abstract Arsenic‐binding proteins are of toxicological importance since enzymatic activities can be blocked by arsenic interactions. In the present work, a novel methodology based on size exclusion chromatography coupled to electrospray ionization mass spectrometry (SEC‐ESI‐MS) was developed wit