Electrospray Ionization Mass Spectra of Amino Acid Methyl Ester 5′-Phosphoramidates of 2′, 3′-Isopropylideneuridine1
✍ Scribed by CHEN, W; GAO, Y; BAI, Y; HAN, D; ZHAO, Y
- Book ID
- 123251867
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 369 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1005-9040
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## Abstract Several amino acid ester cyclohexyl phosphoramidates of AZT as anti‐HIV prodrugs were synthesized and investigated by electrospray ionization tandem mass spectrometry (ESI‐MS^__n__^). A novel methoxy group migration from the carbonyl group to the phosphoryl group was observed in ESI‐MS2
Derivatization using 1-phenyl-3-methyl-5-pyrazolone (PMP) was selected among a number of reported methods for labeling carbohydrates, since it gives a quantitative yield, proceeds through a rapid reaction and involves a simple clean-up procedure. Moreover, PMP derivatives provide an increase in sens