Electroreduction of 4-(nitrophenyl) substituted 1,4-dihydropyridines on the mercury electrode in aprotic medium

✍ Scribed by J.A. Squella; G. Jimenez; S. Bollo; L.J. Núñez-Vergara

• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 668 KB
• Volume: 42
• Category: Article
• ISSN: 0013-4686
• DOI: 10.1016/s0013-4686(96)00406-9

✦ Synopsis

Electrochemical studies on 4-(nitrophenyl) substituted 1,4_dihydropyridines of pharmacological importance have allowed us to generate the one-electron reduction product, the nitro radical anion, ArNO; ~~. in aprotic media. Cyclic voltammetric technique have been employed to study the tendency of ArNOi to undergo further chemical reaction. Second order kinetics for the decay of ArNOI were established for all the 1,4_dihydropyridines

examined. The 1,Cdihydropyridine derivatives that have the nitro group in the orto position in the ring shows a trend to give less stable radicals when comparing with meta substitution. The cyclic voltammograms of the couple ArNO*/ArNO;-has also been examined in the presence and absence of glutathione concluding that it does not exist interaction among glutathione and the nitro radical anions in aprotic media.