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Electroporation Introduction of Diclofenac Sodium into Human Erythrocytes and Its Determination

✍ Scribed by Qian Dong; Daiqing Yu; Xiaoying Ye; Wenrui Jin

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
229 KB
Volume
13
Category
Article
ISSN
1040-0397

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✦ Synopsis

A method of electroporation for introducing diclofenac sodium (a drug) into human erythrocytes was developed. The conditions (the pulse strength, pulse duration and pulse number) for the introduction of diclofenac sodium into erythrocytes by electroporation were investigated. The diclofenac sodium in single human erythrocytes introduced by the electroporation was analyzed qualitatively and quantitatively by capillary zone electrophoresis (CZE) with end-column ampermetric detection at a carbon microdisk array electrode.

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## Abstract The kinetics and oxidation of diclofenac sodium (DFS) by diperiodatoargentate(III) (DPA) in alkaline medium at 298 K and at a constant ionic strength of 0.60 mol dm^βˆ’3^ were studied spectrophotometrically. The oxidation products were [2‐(2,6‐dicloro‐phynylamino)‐phenyl]‐methenol and Ag(