Electrophysiology of dentate granule cells after kainate-induced synaptic reorganization of the mossy fibers
โ Scribed by James Cronin; Andre Obenaus; Carolyn R. Houser; F. Edward Dudek
- Book ID
- 115802918
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 603 KB
- Volume
- 573
- Category
- Article
- ISSN
- 0006-8993
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We sought to describe quantitatively the morphological and functional changes that occur in the dentate gyrus of kainate-treated rats, an experimental model of temporal lobe epilepsy. Adult rats were treated systemically with kainic acid, and, months later, after displaying spontaneous recurrent mot
Dentate granule cells are generally considered to be relatively resistant to excitotoxicity and have been associated with robust synaptogenesis after neuronal damage. Synaptic reorganization of dentate granule cell axons, the mossy fibers, has been suggested to be relevant for hyperexcitability in h