Antiarrhythmic and electrophysiologic ef
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Lewis V. Buchanan; Dwayne D. Thompson; Chang-Yuan L. Hsu; Rodney R. Walters; Joh
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Article
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1995
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John Wiley and Sons
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English
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lbutilide fumarate is a class Ill antiarrhythmic agent in phase Ill clinical trials. Due to rapid hepatic metabolism, ibutilide has a low oral bioavailability (< 10%). To assess alternate routes of administration, we performed repeated studies of the electrophysiologic effects of sublingual ibutilid