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Electrophysiological evaluation of the effects of naftidrofuryl on skeletal muscle reinnervation in the rat

✍ Scribed by Dr. Monique Pécot-Dechavassine; Jean-Claude Mira

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
682 KB
Volume
15
Category
Article
ISSN
0738-1085

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✦ Synopsis

Abstract

The effects of naftidrofuryl on the reinnervation of the rat gastrocnemius muscle after its denervation by localized freezing of the sciatic nerve were tested with electrophysiological techniques. Daily intraperitoneal injections of 30mg/kg of naftidrofuryl do not increase the rate of axonal regeneration since early signs of reinnervation appeared as in controls around the 10th day after surgery. However, axonal sprouting is markedly increased since the percentage of muscle fibers with polyneuronal innervations was almost twice as high as in controls at the 15 and 21 day postoperative stages. The promoting effects of naftidrofuryl on polyneuronal innervation which gives rise to a redundant innervation during the first period of reinnervation constitutes an improvement of motor function which might be efficient for treatment of nerve injury and neuropathies. © 1994 Wiley‐Liss, Inc.

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