Electrophysiological effects of rosiglitazone on heart ventricular papillary muscles of control and diabetic histidine decarboxylase knock-out and wild-type mice

✍ Scribed by Andrea Szebeni; Ágnes Kovács; Valéria Kecskeméti

• Publisher: BioMed Central
• Year: 2011
• Tongue: English
• Weight: 74 KB
• Volume: 11
• Category: Article
• ISSN: 1471-2210
• DOI: 10.1186/1471-2210-11-s2-a53

✦ Synopsis

Gastroesophageal reflux disease (GERD) is a chronic acid-peptic disorder that is the combined result of several factors: 1) the lack of gastrointestinal motility coordination, 2) the failure of the lower esophageal sphincter to prevent reflux, and 3) the caustic nature of the gastric refluxate. Although GERD is very common, only a small fraction of sufferers consult a physician regarding their problem. This disease has a tremendous impact on both quality of life and overall health. If untreated, GERD can result in many serious complications, including erosive esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. Because the caustic nature of the refluxate is a direct cause of esophageal damage, the cornerstone of GERD therapy is gastric acid suppression.