The discovery of the antidepressive effect of imipramine by Kvn~ (1957) initiated much research in this field. P~OTIVA et al. (1957) synthetized in our institute a group of acridan-and phenothiazineaminoalkyl derivatives. One of us (VoTAvA) examined the pharmacological effects of these drugs and found a high antihistaminic effect "in vitro" in the group of acridan derivatives for N'-(3-dimethylaminopropyl)homoacridan hydrochloride. / \gH~CH~/\ II i I /cu~ CH2CH~CH2N~cH3 Imipramine 9 HC1 | II !j | ~/\CH~N/// I /on, CH2CH~CH2N ~ 9 HCI CH3
Propazepine This drug (generic name, propazepine), which is the structural isomer of imipramine was tested with imipramine for comparison of pharmacological effects (METYw and VOTAVA 1962). As long as these substances were tested by the classical pharmacological methods (toxicity, prolongation of thiopental anaesthesia in mice, rotating rod), no significant differences could be observed. Therefore we used electro-physiologieM methods, such as recording of bioelectrical activity of cortical and subeortieal areas in rabbits, measuring of the motoric thresholds in rabbits and the method of self-stimulation according to OLDS in rats.
Methods
1. Bioelectrical activity o i cortical and subcortical areas in rabbits with
implanted electrodes. These experiments were performed in a groups of 6 rabbits with implanted cortical and subcortical electrodes. For cortical electrodes we used nickeled screws of 3 mm diameter: two of them were