Electrophysiological characterisation of motor and sensory tracts in patients with hereditary spastic paraplegia (HSP)
✍ Scribed by Karle, Kathrin N; Schüle, Rebecca; Klebe, Stephan; Otto, Susanne; Frischholz, Christian; Liepelt-Scarfone, Inga; Schöls, Ludger
- Book ID
- 121534706
- Publisher
- BioMed Central
- Year
- 2013
- Tongue
- English
- Weight
- 396 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1750-1172
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Hereditary spastic paraplegia (HSP) is a heterogeneous condition characterised in its pure form by progressive lower limb spasticity. Mutations in SPG4 (encoding spastin) may be responsible for up to 40% of autosomal dominant (AD) cases. A cohort of 41 mostly pure HSP patients from Britain and Austr
Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia of the lower limbs. Autosomal dominant hereditary spastic paraplegia 4 linked to chromosome 2p (SPG4) is the most co