Electrophysiological, behavioral, and chemical evidence for a noncholinergic, stereospecific site for nicotine in rat brain

✍ Scribed by L. G. Abood; K. Lowy; A. Tometsko; H. Booth

• Book ID: 102385640
• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 421 KB
• Volume: 3
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.490030503

✦ Synopsis

Pharmacological, electrophysiological, and biochemical studies have been conducted with rats in a n attempt t o demonstrate that some o f the behavioral effects of nicotine may involve non-cholinergic brain sites. The behavioral response consisted of a prostration-immobilization syndrome following the injection of 1-10 pg of nicotine into the region of the lateral or third transmitters and their antagonists, and a number of other psychotropic drugs were ineffective in either enhancing or antagonizing the action of nicotine. Associated with the behavioral response were distinct electrophysiological patterns recorded from electrodes implanted in the dorsal hippocampus in freely moving rats. The characteristic electrical changes consisted of shifts in