✦ LIBER ✦

Electrophysiological alterations in subthalamic neurons after unilateral dopamine depletion in the rat

✍ Scribed by Mahadevan Gajendiran; Carlos Cepeda; Hoa Ton Kha; Jessica D. Sison; Michael S. Levine

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 288 KB
Volume: 80
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.20455

No coin nor oath required. For personal study only.

✦ Synopsis

The present study examined the effects of unilateral 6-hydroxydopamine (6-OHDA) lesions of the substantia nigra pars compacta (SNc) on electrophysiological properties of subthalamic neurons (STN) in adult rats. Most neurons displayed regular spontaneous tonic firing patterns in both control and lesioned animals; however, the percentage of neurons with spontaneous burst firing at hyperpolarized membrane potentials was increased significantly in lesioned animals compared with controls (45% vs. 14% respectively). In the presence of bicuculline, a g-aminobutyric acid type A (GABA A ) receptor antagonist, electrical stimulation of the internal capsule produced monosynaptic excitatory postsynaptic potentials (EPSPs) in almost all recorded neurons. DA (50 mM) increased the amplitude and/or duration of the EPSPs in neurons from both groups, whereas the DA D1 receptor agonist SKF 81297 (10 mM) produced a significant increase in amplitude and/or duration of EPSPs in neurons from the lesioned group only. This latter increase was blocked by pretreatment with the DA D1 antagonist SCH 23390 (10 mM). These data suggest that unilateral degeneration of DA neurons in the SNc changes firing properties and enhances electrophysiological responsiveness of STN neurons to activation of DA D1 receptors.

📜 SIMILAR VOLUMES

Riluzole reduces hyperactivity of subtha

Riluzole reduces hyperactivity of subthalamic neurons induced by unilateral 6-OHDA lesion in the rat brain

✍ Oum-Kaltoum Hassani; Mireille Mouroux; Georg Andrees Bohme; Jean-Marie Stutzmann 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 91 KB

## Abstract An abnormal increase in the activity of neurons of the subthalamic nucleus is a key pathophysiological feature of Parkinson's disease. We sought to determine whether riluzole, a sodium channel inhibitor that interferes with glutamatergic neurotransmission, affects neuronal activity in t

Acute and chronic administration of the

Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study

✍ Yoshio Minabe; Kiyoshi Matsuno; Charles R. Ashby Jr. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 1 views

In this study, we examined the effect of the acute and repeated administration of the selective sigma () 1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503) on the number and firing pattern of spontaneously active dopamine (DA) neurons in substantia ni

Minor neuronal damage and recovered cell

Minor neuronal damage and recovered cellular proliferation in the hippocampus after continuous unilateral forelimb restraint in normal rats

✍ Akimasa Ishida; Yoshitomo Ueda; Kazuto Ishida; Sachiyo Misumi; Tadashi Masuda; M 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 478 KB

Constraint-induced movement therapy (CIMT) involves the restraint of an intact limb to force the dominant use of an affected limb, in an attempt to enhance usedependent plasticity and reduce dysfunction. To investigate whether forced disuse of an intact forelimb with CIMT causes a loss of limb funct

Chronic clozapine, but not haloperidol,

Chronic clozapine, but not haloperidol, alters the response of mesoprefrontal dopamine neurons to stress and clozapine challenges in rats

✍ Bret A. Morrow; Shelly J. Rosenberg; Robert H. Roth 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 255 KB

Previously, we demonstrated that serotonin-lesioned rats had an enhanced mesoprefrontal dopaminergic response to restraint stress. This study attempted to extend our knowledge regarding this serotonin/dopamine interaction by seeing if suppression of serotonin metabolism by chronic administration of

Plasticity of responses to synaptic inpu

Plasticity of responses to synaptic inputs in rat ventral striatal neurons after repeated administration of the dopamine D2 antagonist raclopride

✍ David M. Finch 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 51 KB

The effects of acute and repeated systemic administration of the dopaminergic D2 antagonist raclopride on responses of ventral striatal neurons were examined in chloral hydrate-anesthetized rats. Stimulating electrodes were placed in the entorhinal and perirhinal cortices, medial thalamus, and preli

The depletion of brain serotonin levels

The depletion of brain serotonin levels by para-chlorophenylalanine administration significantly alters the activity of midbrain dopamine cells in rats: An extracellular single cell recording study

✍ Yoshio Minabe; Kenji Emori; Charles R. Ashby Jr. 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 886 KB

In this study, we examined the effect of 5-HT depletion produced by the acute administration of para-chlorophenylalanine (PCPA) on the number of spontaneously active dopamine (DA) cells in the ventral tegmental area (VTA or A10) and substantia nigra pars compacta (SNC or A9) in the rat. We also dete