Electrophysiological actions of luteinizing hormone-realeasing hormone: Intracellular studies in the rat hippocampal slice preparation
✍ Scribed by Michael Wong; Misty J. Eaton; Robert L. Moss
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 636 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0887-4476
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✦ Synopsis
The electrophysiological effects of luteinizing hormone-releasing hormone (LHRH) on CA1 pyramidal cells were investigated utilizing intracellular recordings from the in vitro rat hippocampal slice preparation. Bath application of LHRH (10-7-10-12 M) resulted in several changes in the electrophysiological properties of CA1 neurons. LHRH induced a long-lasting depolarization associated with increased input resistance, a decrease in the afterhyperpolarization (AHP) following a train of action potentials, and a reduction in accommodation of repetitive cell discharge. These effects were blocked by the synthetic LHRH antagonist [Ac-A-Pro', pC1-D-Phe2, D-Trp3v6]-LHRH. These findings provide electrophysiological evidence for the role of LHRH as a neurotransmitterheuromodulator in the hippocampus.