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Electrophysiologic characteristics of human and rat retinas in vitro

โœ Scribed by Jun C. Huang; Mary J. Voaden; John Marshall; Colin M. Kemp

Publisher
Springer-Verlag
Year
1990
Tongue
English
Weight
387 KB
Volume
76
Category
Article
ISSN
0012-4486

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โœฆ Synopsis

To promote studies on the human retina, we investigated the survival of function in postmortem specimens. Visual pigment has been regenerated in normal human retinas, 5 to 58 hours postmorten, by exposure to retinal isomers in the dark. Levels from 0.1 to 0.41 nmol/ mg protein were reached. Photoresponses were obtained in 9 of 13 retinas: P III maximum amplitudes ranged from 20-398 #V and thresholds, taking the criterion amplitude as 3/~V, ranged from 8.8-1340 quanta/#m 2. In three cases, the b-wave was also seen. The PIII amplitude vs. log intensity curves gave values of n between 0.6 and 1.0, and a (the stimulus intensity for a half maximal response) between 132-3700 quanta/#m 2. Recovery of sensitivity did not always correspond to that of maximum response.

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