Electrophoretic separation of erythrocyte adenosine deaminase in three families with severe combined immunodeficiency
✍ Scribed by G. P. Gutter; H. J. Plüss; W. H. Hitzig
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 746 KB
- Volume
- 173
- Category
- Article
- ISSN
- 0372-8722
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The degree of immunodeficiency associated with deficiency of adenosine deaminase (ADA) is variable. Most patients are infants with severe combined immunodeficiency (SCID), but in about 20 percent immune dysfunction becomes manifest later in childhood ("delayed-onset"); several patients with "late" o
We present a linkage map of DNA probes around the X-linked severe combined immunodeficiency (IMD4) locus at Xq11-13. DXS159 and PGK1 show no cross-overs with the disease locus (Lod 3.01 at theta = 0.00). The order of loci is DXS1-DXS106-(DXS159-PGK1-IMD4)-DXS72 -DXYS1. Members of families whose carr