## Abstract Plasma amyloid‐β peptide (Aβ) levels have been suggested as a biomarker candidate for detecting incipient AD. Aβ peptides are known to be sensitive to distinct preanalytical sample handling, which calls for standardised preanalytical procedures. We investigated serum and plasma samples
Electrophoretic separation of amyloid β peptides in plasma
✍ Scribed by Piotr Lewczuk; Hermann Esselmann; Mirko Bibl; Sabine Paul; Jana Svitek; Johannes Miertschischk; Robert Meyrer; Alexandr Smirnov; Juan Manuel Maler; Christian Klein; Markus Otto; Stefan Bleich; Wolfgang Sperling; Johannes Kornhuber; Eckhard Rüther; Jens Wiltfang
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 163 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0173-0835
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## Abstract For Abstract see ChemInform Abstract in Full Text.
The effects of b-amyloid (25-35) (bA) on cultured astrocytes from rat cortex were studied and compared with those of a scrambled peptide and with untreated cultures. Single addition (from 5 to 200 mg/ml) of bA peptide induced a marked morphological change in astrocytes, changing their flat polygonal
## Background: The ratio of high amyloid-b peptide40 (Ab40) and low Ab42 in plasma predicts the risk of Alzheimer's disease (AD) and is associated with episodic recall in depression. We thus examined the relationship between plasma Ab levels and brain volumes. Methods: Homebound elders (N ¼ 352) w