✦ LIBER ✦
Electrophoretic analysis of four high molecular weight sialoglycoproteins produced by metastatic human colon carcinoma cells
✍ Scribed by T. Irimura; D. A. Carlson; D. M. Ota
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 606 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0730-2312
No coin nor oath required. For personal study only.
✦ Synopsis
Evidence from a number of studies indicates that carcinomas of various origins produce very high molecular weight, highly glycosylated glycoproteins. These so-called mucins have been found associated with mammary, pancreatic, colonic, ovarian, and other carcinoma cells and tumor tissues of human origin [ 1-61. They were also found in the circulating blood of patients with carcinoma [7-111. In many cases, specific monoclonal antibodies generated against carcinoma cells or purified glycolipid antigens were shown to recognize antigenic epitopes expressed on the mucin carbohydrate chains.