Electrophilic substitution in 3- and 4-methyl-2(1h)quinolinone through metallated species
✍ Scribed by Olga Martin; Elena de la Cuesta; Carmen Avendaño
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 565 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
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## Abstract ^15^N NMR spectral data for 3‐substituted (chloro, bromo, acetyl, carboxy, carboethoxy, methylsulfanyl, methylsulfinyl, __N,N__‐dimethylsulfamoyl, nitro) 4(1__H__)‐quinolinones and their 1‐methyl derivatives are presented. Copyright © 2003 John Wiley & Sons, Ltd.
5-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones have been identified with different combinations of 5-HT 1 autoreceptor antagonist and hSerT potencies and excellent rat PK profiles. The availability of tool compounds with a range of profiles
## Abstract magnified image Oxidation of metronidazole (**4**) with sodium dichromate yielded the corresponding 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetic acid (**5**) which was esterified with 1‐butanol to give butyl 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetate (**8**). Reaction of the l