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Electrophilic Condensation of Pyrimidines with Cyclic Ketones

✍ Scribed by On Lee; Hui-po Wang

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
415 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Electrophilic condensation of pyrimidines with cyclic ketones was investigated. As nucleophiles,the degreeof ionizationof pyrimidinesin acidicmedia and the electrondensityon the C-5 determinedthe reactivity.An electron-richnitrogenat the 4-positionof cyclic ketonesfacilitatedthe reaction.This methcd is facilefor the synthesisof 5-vinylsubstitutedpyrimidinesas kcat antifolates. @ 1997Elsevier ScienceLtd.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Electrophilic Conde
ChemInform Abstract: Electrophilic Condensation of Pyrimidines with Cyclic Ketones.
✍ O. LEE; H. WANG πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 26 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

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