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Electropermeabilization of skeletal muscle enhances gene transfer in vivo

โœ Scribed by Mathiesen, I

Book ID
110038371
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
392 KB
Volume
6
Category
Article
ISSN
0969-7128

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## Background: Adenoviral gene transfer to adult skeletal muscle is hindered by several major limitations, including host immune responses and maturation-dependent loss of myofiber infectivity. ex vivo gene delivery is more efficient than direct viral injection in surmounting maturation-dependent a