Electrographic and behavioral effects of diazepam during alcohol withdrawal stage in cats
β Scribed by R. Guerrero-Figueroa; Merrill M. Rye; D.M. Gallant; M.P. Bishop
- Book ID
- 118952970
- Publisher
- Elsevier Science
- Year
- 1970
- Tongue
- English
- Weight
- 806 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0028-3908
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## Abstract We have studied the effects of two anxiolytic drugs frequently prescribed in alcohol withdrawal, diazepam and tetrabamate, on sleep polygraphy of alcoholβdependent patients hospitalized for alcohol detoxification. Twentyβthree inpatients (16 M and 7F) fulfilling the DSM 3R alcoholβdepen
Administration of diazepam at doses that produced ataxia (5-10 mg/kg IP) significantly decreased the discharge rate of substantia-nigral dopamine-containing neurons by 28.1% in freely moving cats. Diazepam also altered the characteristic decremental bursting pattern of these neurons, producing a ste