Electrogenic glutamate uptake in glial cells is activated by intracellular potassium
β Scribed by Barbour, Boris; Brew, Helen; Attwell, David
- Book ID
- 109756573
- Publisher
- Nature Publishing Group
- Year
- 1988
- Tongue
- English
- Weight
- 434 KB
- Volume
- 335
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/335433a0
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Na+-selective, double-barrelled microelectrodes were used to measure intracellular Naf activity (ah,) and membrane potential (Em) in neuropile glial cells of isolated segmental ganglia in the leech Hirudo medicinalis. Bath application of glutamate M) resulted in membrane depolarizations of about 5 m
## Abstract The clearance of synaptically released glutamate is one of the pivotal functions of glial cells. We have studied the role of 5βhydroxytryptamine (5βHT, 30 ΞΌM), a neurotransmitter and neurohormone in the leech central nervous system with a versatile action spectrum, on the efficacy of gl