Electroencephalographic slowing and reduced reactivity in neuropathic pain following spinal cord injury
โ Scribed by Boord, P; Siddall, P J; Tran, Y; Herbert, D; Middleton, J; Craig, A
- Book ID
- 110075106
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 151 KB
- Volume
- 46
- Category
- Article
- ISSN
- 1362-4393
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๐ SIMILAR VOLUMES
## Abstract Damage to the nervous system often results in neuropathic pain. Current treatment for this disabling state is unsuccessful due to our incomplete understanding of cellular mechanisms causing this pain. Although glial cells were largely ignored in most textbooks of pain, accumulating evid
We have previously shown that activation of the ATP-gated ion channel subtype P2X 4 receptors (P2X 4 Rs) in the spinal cord, the expression of which is upregulated in microglia after nerve injury, is necessary for producing neuropathic pain. The upregulation of P2X 4 Rs in microglia is, therefore, a