Electroencephalographic episodes of 1 to 7 per second rhythmic waves following hypothermic hypoxia in developing chicks
✍ Scribed by Peters, Joseph J. ;Vonderahe, Alphonse R. ;Hilgeford, Eric J.
- Book ID
- 102891154
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 870 KB
- Volume
- 170
- Category
- Article
- ISSN
- 0022-104X
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✦ Synopsis
Developing chicks between the day of hatching and three weeks after hatching were subjected to hypothermia of 20°C followed by nitrogenous hypoxia until breathing ceased and the cerebral electroencephalogram was reduced to zero potential. Resuscitation was started 15 minutes later; 86% of the chicks resumed spontaneous breathing. Eighty percent of the resuscitated chicks showed electroencephalographic episodes usually lasting 1 to 3 minutes and consisting of conspicuously rhythmic blunt spike-like waves of large amplitude and complex patterns with frequencies in the range of 1 to 7 waves per second until the episode was terminated at almost zero potential. Monopolar technique using the comb as the reference electrode indicated that the EEG episodes were either predominantly bilateral or unilateral, with both gradual and abrupt changes in amplitude, frequency, and site of origin. During episodes the chicks were either motionless or showed tremors of eyelids, limbs, trunk, with occasional staring and chirping. During progressive recovery, as episodes approached, large amplitude waves increased in amplitude and frequency, and changed from domes to blunt spikes. Similar slow waves apeared during episodes and continued during recovery eventually culminating in normal EEG patterns of sleep, Statistically the younger chicks showed briefer and fewer episodes, with the lowest maximum frequency. On the day following experimentation 86% of the resuscitated chicks were alive and showed normal EEG patterns and behavior: death was not limited to chicks having episodes.