Electrochemically promoted Friedel–Crafts acylation of aromatic compounds

✍ Scribed by G. Karthik; K. Kulangiappar; Frank Marken; M. Anbu Kulandainathan

• Book ID: 104095108
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 113 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.02.084

✦ Synopsis

Friedel-Crafts acylation is carried out with several aromatic substrates in the presence of an electrochemically active aluminium anode to minimize the inorganic reagents. Only a catalytic amount of AlCl 3 (5 mol %) is required to enable the anodic polarization of the aluminium electrode to promote continuous acylation. This process typically gave products in good yields (70-96%).