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Electrochemical Studies of the Hemin-DNA Interaction

✍ Scribed by Feng Qu; Zhiwei Zhu; Nan-Qiang Li

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
187 KB
Volume
12
Category
Article
ISSN
1040-0397

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✦ Synopsis

An electrochemical study of the interactions of hemin with DNA on a hanging mercury drop electrode (in ammonia buffer solution) is described. Adding DNA in hemin solution resulted in decrease of both the hemin reduction peak and the catalytic hydrogen wave. Electrochemically nonactive hemin-DNA complexes are formed due to hemin intercalated into DNA. Then the equilibrium concentration of hemin in solution decreases. In this article, we give some support to the fact that hemin, as a dimer under our experiment, with a large steric structure and anionic substitute on porphyrin plane, shows the abilities to intercalate into DNA.

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