𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Electrochemical oxidation of dacarbazine and its major metabolite (AIC) on carbon electrodes

✍ Scribed by José R. Barreíra Rodriguez; Agustin Costa Garcia; Arturo J. Miranda Ordieres; Paulino Tuñón Blanco

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
377 KB
Volume
1
Category
Article
ISSN
1040-0397

No coin nor oath required. For personal study only.

✦ Synopsis

The electrochemical behavior of the antitumor agent dacarbazine (DTIC) and its major metabolite, 5-aminoimidazole-4-carboxamide (AIC), on carbon paste electrodes has been studied. Linear sweep voltammetry (LSV) and differential pulse voltammetry (DW) have been applied, showing that both molecules are active in oxidation. Both compounds are oxidized in a two-electron process, presenting a charge transfer coefficients ( p ) of 0.44 +-0.03 and 0.48 2 0.03 for DTIC and AIC, respectively, which indicate slow processes. The oxidation mechanisms proposed for each of these compounds seem to yield the same final product, the 5-hydroxyimidazol-4-carboxamide. DW proved to be a valuable analytical technique that is suitable for distinguishing and analyzing both compounds when the most adequate medium (0.1 M HC104) and operating conditions are chosen.

📜 SIMILAR VOLUMES

Study on Electrocatalytic Oxidation of L
Study on Electrocatalytic Oxidation of L-Cysteine at Glassy Carbon Electrode by (FcM)TMA and Its Electrochemical Kinetics
✍ Zuo-Ning Gao; Hui-Qin Yao; Wan-Yi Liu 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB 👁 2 views

## Abstract The electrocatalytic oxidation of L‐cysteine by (ferrocenylmethyl)trimethylammonium at a glassy carbon electrode in 0.1 M Na~2~SO~4~ aqueous solution has been studied. The rate constant for the catalytic reaction was evaluated as (4.28±0.05)×10^3^ M^−1^ s^−1^ by chronoamperometry. Exper