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Electrochemical Monitoring of Nucleic Acid Hybridization by Single-Use Graphene Oxide-Based Sensor

โœ Scribed by Mihrican Muti; Surbhi Sharma; Arzum Erdem; Pagona Papakonstantinou

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
379 KB
Volume
23
Category
Article
ISSN
1040-0397

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โœฆ Synopsis

Abstract

In this paper, the application of a Graphene oxide (GRPox) integrated on singleโ€use pencil graphite electrode (PGE) for the enhanced monitoring of nucleic acids and for the sensitive and selective detection of the label free DNA hybridization related to Hepatitis B virus (HBV) sequences is described. Electrochemical behaviors of GRPox modified PGEs were firstly investigated using electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). The sequence selective DNA hybridization was determined voltammetrically in the case of hybridization between amino linked probe and its complementary (target), or, noncomplementary (NC), or target/mismatch (MM) mixtures (1โ€‰:โ€‰1).

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