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Electrochemical cross-coupling between 2-halopyridines and aryl or heteroaryl halides catalysed by nickel-2,2′-bipyridine complexes

✍ Scribed by Corinne Gosmini; Sarah Lasry; Jean-Yves Nedelec; Jacques Perichon

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
418 KB
Volume
54
Category
Article
ISSN
0040-4020

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✦ Synopsis

2-Arylpyridines can be obtained m good to high yields by electrochemical reduction using the sacrificial anode process and catalysis by nickel-2,2'-bipyridine 0apy) complexes. In a fhst approach functionalized arylzmc species are prepared m DMF as solvent by electrolytic reduction of the corresponding aryl-bromides or -c.hlorides in the presence of ZnBr 2 ~ Ni(II)-bpy complexes and then coupled with 2-chlorepyridine. In a second approach the cross-coupling occurs from the electrochemical reduction of a stoichiometric mixture of an aryl halide and 2-halopyridine in DMF in the presence of NiBr2bpy as catalyst.

📜 SIMILAR VOLUMES

Electrosynthesis of functionalized 2-ary
Electrosynthesis of functionalized 2-arylpyridines from functionalized aryl and pyridine halides catalyzed by nickel bromide 2,2′-bipyridine complex
✍ Corinne Gosmini; Jean Yves Nédélec; Jacques Périchon 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 145 KB

2-Arylpyridines substituted on aryl and/or on pyridine nuclei can be obtained in good to high yields in one step by electroreduction of mixtures of the corresponding aryl and pyridyl halides using the sacri®cial iron anode process and a nickel 2,2 H -bipyridine complex catalyst in DMF as solvent.