Electrochemical behavior of mutagenic nitro and amino derivatives of carbazole

✍ Scribed by Roger Carlier; Eugène Raoult; André Tallec; Vèronique Andre; Pascal Gauduchon; Jean-Charles Lancelot

• Book ID: 102833900
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 539 KB
• Volume: 9
• Category: Article
• ISSN: 1040-0397
• DOI: 10.1002/elan.1140090118

✦ Synopsis

The electrochemical behavior of nitro and amino carbazole derivatives has been investigated. In aprotic medium, both in reduction and oxidation, the electrochemical process is complicated by "father-son" protonation reactions. In protic medium, the hydroxylamines resulting from 4-electron reduction of nitrocarbazoles are unstable in very acidic medium, but relatively stable in acetic or ammoniacal buffer, except for 3-hydroxylaminocarbazole; reduction of amino-nilrocarbazoles leads to unstable hydroxylamines. Oxidation of aminocarbazoles is a 2-electron process, the 2amino compounds being more difficult to oxidize than the 3-amino derivatives. The relationships between these electrochemical behaviors and mutagenic properties of the studied compounds are also discussed.