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Electrochemical behavior of iproplatin at the carbon paste electrode

✍ Scribed by F. Mebsout; J. M. Kauffmann; G. J. Patriarche; J. Vereecken; Gary D. Christian

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
482 KB
Volume
1
Category
Article
ISSN
1040-0397

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✦ Synopsis

The electrochemical redox behavior of iproplatin (JM9) was investigated at the carbon paste electrode using cyclic voltammetry in the absence and presence of free chloride ions. In the absence of chloride, a diffusion-controlled, two-electron reduction peak (E,, ) is observed, giving a platinum( 11) derivative that is oxidized to a Pt(IV) compound on cycling (Epal). Photolytic reduction-hydrolysis to two platinum(I1) derivatives results in a Pt(I1) compound which on anodic scannigg is oxidized to a Pt(IV) compound (Epa2) that is subsequently reduced to a Pt(I1) compound on cycling, to give rise to a second (earlier) reduction peak (EPcz). The other (nonhydrolyzed) photolytic reduction Pt( 11) product can also be reduced (ELc2) to give Pt(0) that subsequently is oxidized to Pt oxides (E&); this latter Pt(I1) compound is prevalent in the presence of chloride ions, which inhibit hydrolysis.

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