𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Electrical activity in cardiac mutant axolotl hearts

✍ Scribed by Epstein, Miles L. ;Lemanski, Larry F.


Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
523 KB
Volume
211
Category
Article
ISSN
0022-104X

No coin nor oath required. For personal study only.

✦ Synopsis


Abstract

Electrical recordings from the hearts of both cardiac lethal mutant and normal embryos showed the presence of action potentials conducted over the heart tube. Ionic coupling and gap junctions also were observed in both. These results suggest that the absence of heart function in mutant embryos does not result from a defect in electrical activity.


πŸ“œ SIMILAR VOLUMES


Heart induction in wild-type and cardiac
✍ Smith, Steven C. ;Armstrong, John B. πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 639 KB

## Abstract We have re‐examined some of the factors affecting the induction of heart‐forming mesodern in the axolotl. The formation of functional, rhythmically contracting myocardial tissue was used as an assay. We have found that heart‐forming mesoderm is fully induced and capable of completing it

Ectopic expression of tropomyosin promot
✍ Robert W. Zajdel; Matthew D. Mclean; Sharon L. Lemanski; Mariappan Muthuchamy; D πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 980 KB

Expression of tropomyosin protein, an essential component of the thin filament, has been found to be drastically reduced in cardiac mutant hearts of the Mexican axolotl (Ambystoma mexicanum) with no formation of sarcomeric myofibrils. Therefore, this naturally occurring cardiac mutation is an approp

Immunofluorescent, immunogold, and elect
✍ Pei-Shen Shen; Larry F. Lemanski πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 825 KB

Recessive mutant gene c for "cardiac nonfunction" in axolotls results in an absence of normal heart contractions in affected embryos due to a failure of myofibril formation. In the present study, the intermediate filament protein, desmin, is compared in developing normal and mutant hearts by means o

Analysis of the endocardium and cardiac
✍ Larry F. Lemanski; Timothy P. Fitzharris πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 790 KB

Recessive mutant gene c in axolotls results in a failure of the heart to function because of abnormal embryonic induction processes. The myocardium in this mutant lacks organized sarcomeric myofibrils. The present study was undertaken to determine if developmental abnormalities were evident in other

Analysis of actin and tropomyosin in hea
✍ Christopher M. Starr; Jose G. Diaz; Larry F. Lemanski πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 751 KB

When homozygous, recessive mutant gene c in Ambystoma mexicanum results in a failure of embryonic heart function. This failure is apparently due to abnormal inductive influences from the anterior endoderm resulting in an absence of normal sarcomeric myofibril formation. Biochemical and immunofluores