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Electric fields and proliferation in a dermal wound model: Cell cycle kinetics

✍ Scribed by K. Cheng; R. J. Goldman

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
117 KB
Volume
19
Category
Article
ISSN
0197-8462

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✦ Synopsis

In a dermal wound model, consisting of human skin fibroblasts in collagen matrix, continuous sinusoidal electrical current stimulation elicited a maximum increase of [ 3 H]thymidine relative to control at 41 mV/m amplitude, 10 Hz. In this paper we elaborate cell cycle kinetics, using the same parameters. Labeling occurred over 4-h intervals beginning at 12 to 20 h after onset of electric exposure. The results suggest a significant increase in [ 3 H]thymidine incorporation over an 8-h period extending from 16 -24 hours after stimulus initiation.

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