Thymidylate synthase polymorphisms and c
โ
Karen Curtin; Cornelia M. Ulrich; Wade S. Samowitz; Jeannette Bigler; Bette Caan
๐
Article
๐
2007
๐
John Wiley and Sons
๐
French
โ 95 KB
## Abstract Thymidylate synthase (TS) is a key enzyme in folate metabolism, a pathway that is important in colorectal carcinogenesis. We investigated the role of functional polymorphisms in the __TS__ 5โฒโUTR promoter enhancer region (__TSER__, 3 or 2 repeats of a 28โbp sequence) and the 3โฒโUTR (__1