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Elastase, collagenase, and cathepsin D activities in the aortas of spontaneously hypertensive and renal hypertensive rats

โœ Scribed by Eiji Yamada; Fumitada Hazama; Shigeru Amano; Masakiyo Sasahara; Hideo Kataoka


Book ID
113147360
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
685 KB
Volume
44
Category
Article
ISSN
0014-4800

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This study of spontaneously hypertensive (SH) rats documents oral antihypertensive activity of the vasodilator Ofornine@, an anthranilamide whose effect was sustained, at least in part, by suppression of compensatory renal and neurohumoral responses. Doses of 2.5 to 100 mg/kg p.0. reduced systolic b